|
KMID : 0389420080160040393
|
|
Korean Journal of Stress Research
2008 Volume.16 No. 4 p.393 ~ p.400
|
|
|
The Neurochemical Study on Antidepressant Effect of Nelumbinis Semen Extract
|
|
Kim Ji-Hyun
Bae Hyun-Su
Lee Kyu-Sop
Shim In-Sop
Kim Kyung-Soo
Joung Hye-Young
Shim Hyun-Soo
|
|
|
Abstract
|
|
|
|
In the previous study, we examined that a variety of extracts of Nelumbinis semen (NS) have an antidepressant effect on the forced swimming test (FST) in the rat, which is widely used as a behavioral screening test for antidepressant activity of new compounds. Depression-like symptom in n-BuOH extract showed the strongest inhibitory effect on the immobility time and further fractionated n-BuOH with H2O and MeOH (3:7) fraction (NS37) was the most effective on the immobility time on FST. The purpose of the present study was to observe the neurochemical changes on the anti-depressant actions of unknown compounds in the NS37 extract by using HPLC coupled with electrochemical detection (ECD). The results showed that the NS37-10 (10 mg/kg) has a significant increase of dopamine in cortex, hypothalamus, and hippocampus and a significant decrease of dopamine turnover in hypothalamus and hippocampus. These neurochemical actions of NS37 extract could be responsible for the beneficial effect on depression.
|
|
|
KEYWORD
|
|
|
Nelumbinis Semen, Antidepressant Effect, HPLC, Neurotransmitter, Brain
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|